Why Develop Bispecific Aptamer Chimeras? Rapid and specific reduction in the abundance of specific membrane proteins would facilitate the development of therapeutic strategies for targeting membrane proteins. Strategies to control the abundance of membrane protein targets rely primarily on interference with gene expression, however, the application of these genetic engineering approaches is...

Computer-aided drug design (CADD) is a method based on computer chemistry to design and optimize lead compounds through computer simulation, calculation and budgeting of the relationship between drug and recipient biological macromolecules. The method of CADD began in the early 1980s. The combination of Computer aided molecular modeling and rational drug design has developed into a large...

The main goal of packaging is to protect the contents from damage and leaking so that they can be distributed safely from one place to another at some given time. No matter for food distribution, pharmaceutical packaging, cosmetics, home-care materials, and many other essential products in modern life, all need appropriate packaging, and polymers, or plastics very often provide the optimal...

Liquid crystals display a hybrid of liquid and solid properties. They are composed of long, thin, rod-like or disk-shaped molecules that have the ability to orient themselves in an orderly fashion without forming a uniform crystalline lattice. This property gives them a distinct orientation that can be altered by external stimuli such as electric or magnetic fields or temperature. Liquid...

The accurate and efficient chiral separation of enantiomeric compounds is very important in fields such as pharmaceuticals, pesticides, and synthesis development. The striking differences in the chemical and physiological properties between enantiomers make these separations a key requirement in the development of many drugs. Often, only one enantiomer exhibits the desired therapeutic benefit,...

Although RNAi is considered to be more effective in treating diseases compared with other methods, there are still some challenges in delivering small interfering RNA (siRNA) to diseased sites for gene therapy. Nanoparticles have unique advantages compared with other carriers and been paid attention to for RNAi delivery. Nanoparticles are particulate dispersions or solid particles with a...

BOC Sciences provide stable isotopes (such as 13C, 15N, 18O, 2H, etc.) analysis and determination services for various research fields. Our laboratory is equipped with isotope-ratio mass spectrometers (IRMS), element analyzers, gas chromatography, mass spectrometer, and other state-of-the-art equipment to analyze samples’ isotope ratio and element content. Our...