The global bone substitute and allograft bone market size was valued at USD 3.1 billion in 2021 and is poised to grow at a significant CAGR of 6.1% during the forecast period 2022-28. Bone grafts and substitutes are used to replace missing bones and to treat fractures. They are made up of an osteoconductive matrix that functions as a filler to aid wound healing, osteoinductive proteins that encourage the mitogenesis of similar bone cells, and osteogenic cells that produce the bone in the proper environment. They are bioresorbable and do not elicit an antigen-antibody response. These characteristics make them popular for treating fractures as well as bone injuries, as well as spinal, face, foot, ankle, and trauma procedures.

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The Global Bone Substitute & Allograft Bone Market is predicted to develop due to the rising frequency of bone cancer. The increased frequency of bone cancer is likely to fuel demand for bone grafts and substitutes, boosting market expansion during the forecast period. Furthermore, the increased use of dental bone grafts is propelling the market forward. Dental bone grafts are becoming more popular due to their better success rate. In 2018, the journal Minim Invasive Surgery reported that minimally invasive treatments were used to treat a wide spectrum of bone problems. The minimally invasive techniques have various advantages, including less pain, a shorter recovery time, and less tissue damage. As a result, medical experts prefer MIS to open surgery. Furthermore, technological advancements in the incorporation of human growth factors into bone grafts with osteoconductive and osteoinductive properties, also including demineralized bone matrix, bone morphogenetic proteins, & platelet-rich plasma (PRP), are anticipated to provide market players with growth opportunities in the Global Bone Substitute & Allograft Market during the forecast period.

On the basis of Type, the market is bifurcated into Bone Graft Substitute, Allograft, and Cell-based Matrices. On the basis of Application, the market is bifurcated into Craniomaxillofacial, Dental Bone Grafting, Joint Reconstruction, Trauma, and Spinal Fusion. The highest revenue share belongs to Spinal Fusion. Spinal fusion is a procedure for repairing minor bone abnormalities in the spine.

The global bone substitute and allograft bone market segmentation:

1) By Products: Allografts (Machined Allografts and Demineralized Bone Matrix).

2) Bone Grafts Substitutes: Bone Morphogenic Proteins (BMP) and Synthetic Bone Grafts), and Cell-Based Matrices).

3) By Application: Craniomaxillofacial, Dental, Foot & Ankle, Joint Reconstruction, Long Bone, and Spinal Fusion.

Geographically, the global Bone Substitute & Allograft market is dominated by North America. This is due to growing regional knowledge of the relevance of bone grafting treatments. Furthermore, rising usage of cell-based matrices is assisting in the region's bone graft market expansion. In North America, the United States has the largest market for Bone Substitute & Allograft, followed by Canada. Germany, Italy, the United Kingdom, and France dominate the European bone graft market. However, Asia is predicted to rise rapidly in the global Bone Substitute & Allograft market during the next five years. This is attributable to the region's growing public understanding of bone regeneration. The fastest-growing Bone Substitute & Allograft markets in Asia are predicted to be Japan, China, and India.

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There are several industry players working in the bone substitute and allograft bone market, which include Medtronic (U.S) Stryker Corporation (U.S) AlloSource (U.S) Baxter (U.S) Orthovita, Inc. (U.S) Smith and Nephew Inc. (U.S) NuVasive, Inc. (U.S) Wright Medical Group N.V (U.S)

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